In vitro activity of ceftizoxime against Bacteroides fragilis: comparison with benzylpenicillin, cephalothin, and cefoxitin

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In vitro activity of ceftizoxime against Bacteroides fragilis: comparison with benzylpenicillin, cephalothin, and cefoxitin.

Minimum inhibitory concentrations of ceftizoxime for seven clinical isolates of Bacteroides fragilis were found to be markedly affected by inoculum size; the very low minimum inhibitory concentration values (less than or equal to 0.25 microgram/ml) obtained in tests with most strains were not sustained when the inoculum was raised 100-fold. Benzylpenicillin and cephalothin were also affected by...

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Activity of ceftizoxime and comparative compounds against Bacteroides fragilis in a mouse model of anaerobic infection.

A new mouse model of anaerobic infection with Bacteroides fragilis alone or in a mixed infection with Escherichia coli is described. It is established by implantation under the skin of a filter paper disk saturated with the appropriate bacterial suspension. The penetration of antibiotics into the implantation site can be detected by assaying the disk. The local infection can be both standardize...

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Htibacterial activity ceftizoxime and its comparison with that of chloramphenicol, penicillin G, cephalexin, cefzoline and cephalothin

This study compares the inhibitory effect of ceftizoxime with that of penicillin G, chloramphenicol, cephalothin, cephalexin and cefzoline on Klebsiella pneumoniae, Proteus mirabilis, pseudomonas ruginosa, staphylococcus aureus, staphylococcus epidermidis, staphylococcus saprophyticus and Escherichia coli. The in vitro inhibitory effect of ceftizoxime on P. mirabilis, P. Aeruginosa, S.prophytic...

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In vitro comparison of cefoxitin, cefamandole, cephalexin, and cephalothin.

The in vitro effect of cefoxitin, cefamandole, cephalexin, and cephalothin was tested against 645 strains of bacteria recently isolated from clinical sources. Against gram-positive organisms cephalothin and cefamandole were the most effective, generally being three- to fourfold more active than cephalexin or cefoxitin. Enterococci were not inhibited by less than 25 mug of any of the antibiotics...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1981

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.20.3.332